I found some plays require you to flick in the designed direction to flip. Might be misdirections. Haven’t paid close attention
If there is motion involved in the play, you can't flip it (there may be exceptions). I have also found that if you move a player before trying to flip the run, it won't let you for some reason. You know, because who would want to move a blocker into position if it's a zone defense or flip it back if it's a man defense? That's a crazy idea.
Zone run plays you can’t - on dive plays flick the right stick in the direction you want to run
How do you switch the side of the run without flipping the whole play?